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Researchers discover a new function of the cerebellum

Illustration of the brain with highlighted areas
The cerebellum (activation in red) connects with different areas of the cerebrum (activations in green) to enhance the storage of emotional information. (Image: MCN, University of Basel)

The cerebellum is known primarily for regulation of movement. Researchers at the University of Basel have now discovered that the cerebellum also plays an important role in remembering emotional experiences. The study appears in the journal PNAS.

06 October 2022

Illustration of the brain with highlighted areas
The cerebellum (activation in red) connects with different areas of the cerebrum (activations in green) to enhance the storage of emotional information. (Image: MCN, University of Basel)

Both positive and negative emotional experiences are stored particularly well in memory. This phenomenon is important to our survival, since we need to remember dangerous situations in order to avoid them in the future. Previous studies have shown that a brain structure called the amygdala, which is important in the processing of emotions, plays a central role in this phenomenon. Emotions activate the amygdala, which in turn facilitates the storage of information in various areas of the cerebrum.

The current research, led by Professor Dominique de Quervain and Professor Andreas Papassotiropoulos at the University of Basel, investigates the role of the cerebellum in storing emotional experiences. In a large-scale study, the researchers showed 1,418 participants emotional and neutral images and recorded the subjects’ brain activity using magnetic resonance imaging.

In a memory test conducted later, the positive and negative images were remembered by the participants much better than the neutral images. The improved storage of emotional images was linked with an increase in brain activity in the areas of the cerebrum already known to play a part. However, the team also identified increased activity in the cerebellum.

Illustration of the brain with highlighted areas
The cerebellum (red) and different areas of the cerebrum (green) interact to enhance the storage of emotional information. (Animation: MCN, University of Basel)

The cerebellum in communication with the cerebrum

The researchers were also able to demonstrate that the cerebellum shows stronger communication with various areas of the cerebrum during the process of enhanced storage of the emotional images. It receives information from the cingulate gyrus – a region of the brain that is important in the perception and evaluation of feelings. Furthermore, the cerebellum sends out signals to various regions of the brain, including the amygdala and hippocampus. The latter plays a central role in memory storage.

Original publication

Matthias Fastenrath et al.
Human cerebellum and corticocerebellar connections involved in emotional memory enhancement.
PNAS (2022), doi: 10.1073/pnas.2204900119


Further information

Prof. Dr. Dominique de Quervain, University of Basel, Research Platform Molecular and Cognitive Neurosciences, phone +41 61 267 02 37, email: dominique.dequervain@unibas.ch

Basel research on emotions and memory

The current study forms part of a large-scale research project conducted by the Research Platform Molecular and Cognitive Neurosciences (MCN) at the University of Basel and the University Psychiatric Clinics (UPK) Basel. The aim of this project is to gain a better understanding of emotional and cognitive processes and to transfer results from basic research to clinical projects.
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