After nerve injury, the protein complex mTORC1 takes over an important function in skeletal muscle to maintain the neuromuscular junction, the synapse between the nerve and muscle fiber. Researchers at the University of Basel’s Biozentrum have now shown that the activation of mTORC1 must be tightly balanced for a proper response of the muscle to nerve injury.
Adjusting the thermal conductivity of materials is one of the challenges nanoscience is currently facing. Together with colleagues from the Netherlands and Spain, researchers from the University of Basel have shown that the atomic vibrations that determine heat generation in nanowires can be controlled through the arrangement of atoms alone. The scientists will publish the results shortly in the journal Nano Letters.
Acute myeloid leukemia stem cells elude the body’s immune cells by deactivating a danger detector. The underlying mechanisms and the potential new therapeutic approaches that this gives rise to have been detailed in the journal Nature by researchers from the University of Basel and University Hospital Basel in collaboration with colleagues in Germany.
The translation of the genetic code into proteins is a vital process in any cell. Prof. Mihaela Zavolan’s team at the Biozentrum, University of Basel, has now uncovered important factors that influence the speed of protein synthesis in the cell. The results, recently published in “PNAS”, serve as a basis to better analyze translational control in a wide range of cell types.
Sustainable means of mobility are becoming ever more popular. In Switzerland, around 15,000 people have registered with the online platform carvelo2go, which hires out electric cargo bikes. The use of this sharing service in the Basel area is now the subject of scientific investigation. Despite strong growth in member numbers, there are still fundamental barriers. The study by the University of Basel indicates ways that sharing providers and public authorities can promote the use of environmentally friendly cargo bikes.
On behalf of social security institutions, psychiatrists assess to what extent people with mental health problems are still able to work. However, the work capability assessments tend to be far too dissimilar. A new training course has helped to reduce the differences. This confirms a study conducted by researchers at the University of Basel and the University Hospital of Basel and financed by the Swiss National Science Foundation.
An international team of researchers involving members of the University of Basel’s Biozentrum challenges the conventional understanding of the cause of Parkinson’s disease. The researchers have shown that the inclusions in the brain’s neurons, characteristic of Parkinson‘s disease, are comprised of a membranous medley rather than protein fibrils. The recently published study in “Nature Neuroscience” raises new questions about the etiology of Parkinson’s disease.
Sports scientists from the University of Basel found that providing telephone-based coaching over the phone is an effective method for getting people in Switzerland to adopt a physically active lifestyle.
When we train the reaching for and grasping of objects, we also train our brain. In other words, this action brings about changes in the connections of a certain neuronal population in the red nucleus, a region of the midbrain. Researchers at the University of Basel’s Biozentrum have discovered this group of nerve cells in the red nucleus. They have also shown how fine motor tasks promote plastic reorganization of this brain region.